Cytokines that regulate liver cancer
February 15, 2019 Source: Science and Technology Daily Author: Li Jing Xie Kaifei
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];The reporter learned from Xiamen University that the team of the State Key Laboratory of Cellular Stress Biology, Professor Zhou Dawang, discovered and identified a cytokine present in the blood, which can regulate bile acid metabolism through specific mechanisms, thereby controlling liver regeneration, size and Carcinogenesis provides an important theoretical basis for regulating the clinical application of liver regeneration and preventing liver cancer. The latest research results were published in the international journal Developmental Cells.
In recent years, Hippo signaling pathway has become a hot research field at home and abroad, which is considered to play an important regulatory role in tissue regeneration, organ size and tumorigenesis. In this study, Professor Zhou Dawang first used mouse concomitant symbiosis experiments and advanced mass spectrometry techniques to discover that a cytokine in serum can activate key kinases in the Hippo signaling pathway, activate the pathway, and inhibit liver growth. . Their further study found that this mechanism can regulate bile acid metabolism and make it in a steady state. When the Hippo signaling pathway is disabled, it will lead to abnormal bile acid metabolism in mice and a large accumulation of bile acids in the body. High levels of bile acids can promote liver. It grows bigger and eventually produces tumors. When feeding mice with cholestyramine which lowers the level of bile acid in the body, it can effectively alleviate liver overgrowth and tumor formation.
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