Release date: 2017-12-01
A research team from Duke University in the United States recently revealed that they have developed a fully functional heart muscle that can be made large enough to repair heart muscle tissue death from a heart attack. This breakthrough has taken an important step toward the ultimate goal of repairing dead heart muscle in human patients. The study was recently published in the top journal Nature Communication, title: Cardipopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues
The heart differs from other human organs in that the heart muscle cannot regenerate after a heart attack because the scar tissue that replaces the dead muscle cannot receive or transmit the necessary electrical signals that are systolic and mandatory. It is necessary to pump blood to the whole body. It is reported that heart failure affects 12 million people worldwide.
Ilia Shadrin, the first author of the article and a PhD in biomedical engineering at Duke University, said that at present, the goal of almost all therapies is to reduce the symptoms associated with the damaged heart, and there is no way to replace the heart muscles that have lost function, because these Once the heart muscle dies, it will not grow up again. Using our method, we can replace the heart muscles that have lost function with heart muscle tissue cultured in vitro.
Although some clinical trials are currently testing to inject stem cells from the bone marrow, blood, or heart itself into organs to regenerate damaged tissue, the understanding of the mechanisms behind the few positive prognosis is modest. In contrast, ongoing cardiac repair studies, despite adequate medical solutions, must be large enough to have a strong electrophysiological activity like natural heart tissue to allow electrical signals to pass. The new intervention developed by Duke University is the first patch to meet these criteria. It is 16 square centimeters in size and 5-8 cells thick. It can even secrete enzymes and growth factors to promote the regeneration of damaged tissues.
Nenad Bursac, a professor of biomedical engineering at Duke University, says that creating a single cardiomyocyte is a common occurrence, but current research has focused on growing small tissues for drug development, expanding its size to repair the heart. It has never been seen before, and it requires a lot of originality in biomedical engineering.
The team's heart muscle tissue patch is based on human pluripotent stem cells, a type of cell that matches any type of tissue in the body and can be made: cardiomyocytes (responsible for muscle contraction), fibroblasts (for Cardiac tissue provides a structural framework), vascular endothelium and smooth muscle cells (forming blood vessels).
Professor Nenad Bursac said that creating this heart muscle patch is very difficult, because the bigger the tissue, the harder it is to maintain consistent performance. Equally challenging is how to make tissue patches mature in as little as five weeks, while at the same time achieving the tissue properties that humans typically require for years of normal development.
Currently, the team has demonstrated that this heart muscle tissue patch survives and is able to vascularize and function in both mouse and rat hearts. Now, in order to be able to be used in the heart of humans, this heart patch must be thick enough, which is the problem that the team is currently working hard to overcome. (Sina Pharmaceutical Compilation/newborn)
Article, picture reference source: Fully Functioning Artificial Human Heart Muscle Developed
Source: Sina Pharmaceutical News
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