New cells found in the regeneration of frog tails - hopefully in mammals
May 20, 2019 Source: Science and Technology Daily
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Science and Technology Daily, Beijing, May 19 (Reporter Liu Xia) According to a recent report by the physicist organization network, will the tail of the frog be regenerated? This is a mystery that has plagued people for more than 2,000 years. Now, British scientists have discovered a special group of skin cells called "regeneration-tissue cells" that can help the frog's tail regenerate. This new study, published in the recently published journal Science, not only helps explain the above-mentioned major mysteries, but also provides clues on how to achieve this capability in mammalian organizations.
As early as the 4th century BC, Aristotle observed that some animals' tails can grow again after amputation, but what kind of mechanism is needed to support this regenerative potential? We still know very little about it.
Now, scientists at the University of Cambridge's British Cancer Institute use "single-cell genomics" to develop a clever strategy that reveals the changes in different cells during the regeneration of the scorpion tail. Specifically, “single-cell genomics†allows them to track which genes are turned on (expressed) throughout the organism or tissue at the resolution of a single cell, so they can be distinguished differently based on the cell's choice of active genes. Cell type.
With this technology, Ken Azteckin and Tom Hickcock analyzed cells associated with regeneration of African clawed frogs after injury.
Hickcock said: "The tails of the dragonfly can be regenerated all the time, but in the precise stage of development, they will lose this ability for two days. We use this natural phenomenon to clarify which cells in the sputum can regenerate and which cells can't. regeneration."
They found that stem cell regeneration is "planned" by a subpopulation of epidermal (skin) cells, regenerative-tissue cells (ROCs).
Azteckin said: "This amazing process is slowly unfolding in front of us: after amputation of the tail, ROCs migrate from the body to the wound and secrete a series of growth factors that coordinate the reaction of the tissue precursor cells. Then these cells are together Work to regenerate the tail, and the regenerated tail has the right size, pattern and cell composition."
The study's co-author, Professor Benjamin Simmons, said: "Understanding the mechanisms that enable some animals to regenerate entire organs is the first step in understanding whether it is possible to reawaken and exploit similar phenomena in mammalian tissues, which is important for clinical applications. ""
Editor-in-chief
In the natural selection of hundreds of millions of years, life has evolved many magical abilities, such as strong sense of smell, hearing, and ability to recognize direction. The frog tail can be regenerated as part of it. It is worth pointing out that we can't be satisfied with only understanding these superficial phenomena, but we should uncover the mechanisms behind these magical abilities and go deep into the cellular and genetic level to find the answer. This will help to deepen the understanding of the mechanism of life, and may also be beneficial to future medical applications.
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