March 19, 2007 — In a groundbreaking development, Japanese scientists have taken a significant step toward creating artificial blood vessels using an unusual source: squid skin. Researchers from Hokkaido University have successfully extracted collagen from the skin of squids and modified it to create functional artificial blood vessels that could one day be used in treating heart conditions such as myocardial infarction.
Through advanced techniques, the team managed to enhance the heat resistance of the collagen, raising its stability to 55 degrees Celsius. This was achieved by altering the molecular structure of the collagen and strengthening the bonds between its molecules. Using this improved material, they fabricated an artificial blood vessel with an inner diameter of 1.6 mm and a wall thickness of 0.6 mm.
In late February, the artificial vessel was implanted into the abdominal aorta of a rat. The results were promising—after transplantation, the artificial blood vessel demonstrated rhythmic expansion and contraction in sync with the rat's heartbeat. It also showed comparable strength and elasticity to the natural aorta, indicating great potential for future medical applications.
This innovation follows earlier efforts by Kyushu University, where researchers developed a double-layered artificial blood vessel using polyurethane. Their design was praised for being soft, flexible, and significantly more effective than previous models.
As research continues, these advancements bring us closer to a future where artificial blood vessels may offer life-saving solutions for patients suffering from cardiovascular diseases. The collaboration between biology and materials science is proving to be a powerful force in medical innovation.
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