According to the British Daily Mail, at present, Organovo, California, USA uses a 3D printer to create a miniature liver organ with a depth of only 0.5 mm and a width of 4 mm, but it has many major functions of real liver organs, including the production of transport hormones. Protein, which delivers salt and drugs to the body.
Scientists at Organovo, Calif., use bioprinters to print "micro livers" layer by layer in the lab.
Miniature liver organs have many real organ functions, including: production of important proteins and cholesterol
Organovo used a 3D printer to print about 20 layers of living cells layer by layer, thus establishing the micro-organ, accompanied by cells from the blood vessels to the liver organs, delivering nutrients and oxygen. It is vital that the addition of blood cells means that this 3D honeycomb can survive for more than 5 days.
Mini-hepatic organs form a large contrast with 2D cultured cells, which are based on single or double-layer cells and survive for only 2 days, and do not have the unique function of Organovo's development of miniature livers. The company is committed to the development of truly sized organs that can be transplanted. Currently, this miniature liver can produce albumin, as well as cholesterol and cytochrome P450s, which can metabolize drugs in liver organs and are a detoxifying enzyme. .
The true structure and function of the miniature liver organ, combined with the hepatocyte layer and the hepatic astrocyte layer, can have a positive impact on the study of infectious diseases, or monitor drug therapy. It can perform blood filtration, metabolism and delivery of drugs, and produce some proteins that are essential for homeostasis.
Some family genetic diseases are often closely related to the lack of protein, which is produced by the liver. At present, scientists at the San Diego Laboratory in California will print a large network of blood vessels to nourish human organs of actual size.
It is reported that Organovo's 3D printer has two print heads, one for printing scaffolding and the other for printing human cells layer by layer to form an organ structure.
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