Release date: 2008-03-10
In a groundbreaking development, the University of Pennsylvania School of Medicine has successfully created the first human nerve cell tissue system, forming a living network of neural cells. This innovation allows for the rapid transplantation of a cellular mesh into the body, which can help repair damaged nervous systems within just a few days. The potential of nerve cell transplantation in treating neurological damage, including conditions like Parkinson’s and Alzheimer’s, has long been recognized. While previous studies using animal models have shown promise, the transition to large-scale clinical applications has remained a challenge due to limited availability of suitable neurons for treatment. Now, researchers have developed a three-dimensional neural network that mimics a small nervous system, making it possible to produce transplantable tissue on a larger scale. By obtaining thoracic neurons from organ donors and spinal nerve ganglion neurons from patients who had undergone gangliontomy, scientists were able to purify and grow these cells in a specialized environment. Using a stretch growth technique, axons were gradually extended over time to reach the desired length. These neurons survived for at least three months, maintaining their ability to generate and transmit electrical signals as they grew. This breakthrough marks the creation of the first functional living human tissue structure. Researchers also confirmed that both autologous (from the patient themselves) and allogeneic (from a donor) methods of acquiring nerve cells are equally viable. Experts believe this discovery highlights the effectiveness, feasibility, and controllability of human nerve cells as a promising material for nerve grafts. ——Shanghai Medical Device Industry Association
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