Release date: 2008-03-10
In a groundbreaking development, researchers at the University of Pennsylvania School of Medicine have successfully created the first human nerve cell tissue system. This innovative approach involves constructing living cells into a functional network that can be transplanted into the body to repair damaged nervous systems. According to the study, this mesh-like structure can be ready for transplantation within just a few days.
Nerve cell transplantation is considered one of the most promising treatments for neurological damage, including conditions like Parkinson’s and Alzheimer’s disease. While previous research using animal models has shown promise, there has been a significant gap in scaling up these techniques for widespread clinical use. One major challenge has been the limited availability of neurons suitable for repair. However, this new development addresses that issue by creating a three-dimensional neural network that can be produced in large quantities for medical applications.
The research team used four thoracic neurons obtained from organ donors and spinal nerve ganglion neurons from 16 patients who had undergone gangliontomy procedures. These cells were purified and placed in a specialized growth chamber. Using a stretch growth technique, the axons were gradually extended over time to achieve the desired length. Remarkably, the neurons remained viable for at least three months, maintaining their ability to generate action potentials—electrical signals that travel along nerve fibers. This process led to the creation of the first living human tissue structure designed for nerve grafting.
Additionally, the study confirmed that both autologous (from the patient themselves) and allogeneic (from a donor) methods of obtaining nerve cells are equally effective. Experts highlight that this breakthrough demonstrates the potential of human nerve cells as a reliable and controllable material for nerve grafts. This advancement could significantly impact the treatment of neurological disorders and bring us closer to personalized, scalable therapies. ——Shanghai Medical Device Industry Association
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