Chinese experts found the underlying pathogenesis of hepatic ischemia-reperfusion injury
December 20, 2017 Source: Xinhuanet
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Hepatic ischemia-reperfusion injury is an inevitable complication during liver resection and liver transplantation. Experts in our country have found that lipid metabolism disorder in the ischemic phase is an early decisive trigger in the process of hepatic ischemia-reperfusion injury, which directly leads to organ failure and acute and chronic tissue rejection after liver transplantation.
The latest research results in the field of hepatic ischemia-reperfusion injury in the Department of Cardiovascular Medicine of Wuhan University People's Hospital, Li Hongliang, found the root cause of liver ischemia-reperfusion injury, which was published in the international top journal Nature Medicine.
At this stage, liver resection and liver transplantation are the most common and effective treatments for end-stage liver disease. Statistics show that hepatic ischemia-reperfusion injury can cause 10% of organ failure after early liver transplantation, 45% of acute and chronic tissue rejection and organ damage, which greatly limits the indications for liver resection and marginal liver donors. Applications.
Funded by the National Science Fund for Distinguished Young Scholars, the National Natural Science Foundation, the National Science and Technology Support Program, and the National Key Research and Development Program, Professor Li Hongliang used the combination of transcriptomics, proteomics and metabolomics to reveal the lipids in the ischemic phase for the first time. Metabolic disorder is an important disease in the process of liver ischemia-reperfusion injury. Among them, the up-regulation of 12-lipoxygenase (ALOX12) and the accumulation of 12-hydroxyeicosatetraenoic acid (12-HETE) were particularly significant, and inflammation and cell death were follow-up events of lipid metabolism disorder.
Experts believe that this study found the underlying pathogenesis of hepatic ischemia-reperfusion injury, filling the gap in previous studies of clinical liver ischemia-reperfusion injury, and finding a new breakthrough for the treatment of liver ischemia and reperfusion.
It is reported that Professor Li Hongliang established the world's first non-human primate rhesus liver hepatic ischemia-reperfusion model, systematically and long-term monitoring of ML355 inhibition in the liver protection of rhesus liver during liver ischemia and reperfusion. effect. The research has applied for 4 patents for drug development and clinical application, and is working with drug development companies to develop relevant clinical drugs.
DisposableDental Kit,including variety of dental appliances accoding to customer's requirement.Widely usd in clinic by dentists.
One Kit usually contains:
1. Dental mirror/1pcs
2. Probe/1pcs
3. Cotton roll /2pcs
4. Iron Forceps/1pcs
5. Medical Scarf/1pcs
6. Tray/1pcs
Dental Kit,Disposable Dental Kit,Plastic Dental Kit
Luck Medical Consumables Co.,LIMITED , https://www.luckmedical.com