According to a report by the Physicist Organization Network, a research paper published in the Journal of the Public Science Library and Biology published on the 5th shows that the analysis of the genomic data of 210,000 people in the United Kingdom and the United States found that it is less common in long-lived people. Genetic variation associated with Alzheimer's disease and severe smoking suggests that natural selection has been "working hard" to eliminate variations in these unfavorable populations.
Further studies have found that genetic mutations associated with heart disease, high cholesterol, obesity and asthma are also less common in long-lived populations. "This is a subtle signal," said Joseph Pickler, a professor at Columbia University and a geneticist at the New York Center for Genetics. "Genetic evidence suggests that the natural selection mechanism of modern humans is still working."
When a genetic mutation occurs, the vital signs change. The inheritance of beneficial mutations between generations makes the relevant features more and more common in the population, and evolution occurs in real time. The genetic technology revolution allows biologists to compare the genetic information of hundreds of thousands of people to explore the natural selection process. By tracking the relative increase or decrease in multiple generations of specific mutations, it can be inferred which evolutionary features are spreading or shrinking.
This time, the researchers analyzed the 60,000 European pedigree genome of the Caesar Permanent Gene Bank in California, and the 150,000 genetic data of the British Life Bank. They were surprised to find that two common genetic mutations—ApoE4 associated with Alzheimer's disease and CHRNA3 mutations associated with severe smoking—have “out of the box†from the entire human genome, directly affecting human lifespan.
Evolutionary biologist Molly Plize Voxke explained that "men who do not carry these harmful mutations can have more descendants of their children", perhaps indicating that natural selection has actively eliminated similar harmful mutations.
The researchers analyzed a group of genetic mutations associated with 42 common features and found that life characteristics such as high cholesterol, high body mass index, heart disease, and asthma were associated with shorter lifespans; genetically determined puberty delays and reproductive age delays, Will reduce mortality.
Source: Technology Daily
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