In the 1966 film "The Magical Journey," a laboratory scientist in the United States compressed a submarine called "Amoeba" and its human members into miniature sizes, and then injected the device into the sick scientist. Inside the body. Inside the body, the engine pushes the "amiamorph" through the blood vessels into the brain, where members of the submarine wear diving equipment and perform precise surgery using a laser gun.
From our perspective of the 21st century, "Magic Journey" is simply a naive and ridiculous film; however, the concept of surgery on a microscopic scale is moving from science fiction to reality. Thanks to the development of technologies such as micro-manufacturing, researchers are making medical devices smaller and smaller, and it is expected that these medical devices will be small enough to pass through the human body in the future.
About a decade ago, a whimsical design emerged: a micro-robot driven by a bull's sperm, bacteria, or star-shaped miniature pliers (which can rotate the arm around a shaft in a warm place) to transport DNA to The rotating magnetic helix of the cell, the steerable magnetic sphere filled with the drug, the micro-motor powered by the stomach acid, and the "miniature scallop" that can fan through the vitreous of the spectacle.
At present, most of these ideas are still the concept and imagination of the laboratory, but some have already begun animal testing. Some engineers also believe that these little things will one day be applied to the pharmaceutical industry. “Our biggest impact will be in the healthcare industry,†said micro-robot expert Metin Sitti, who heads the physical intelligence division of the Max Planck Institute at Intelligent Systems in Germany.
The researchers say that by using the right design, a micro-robot (or robotic worm) can be used to deliver highly targeted drugs or radioactive blocks, remove blood stasis, perform tissue biopsy, or build a new cell. The stent on which it is grown.
These types of activities can help expand the two existing trends in the pharmaceutical industry: early disease diagnosis and more precise targeted therapies. Bradley Nelson, professor of robotics and intelligent systems at the Federal Institute of Technology in Zurich, said: "The dream is to achieve "magic journey."
To achieve this dream means to overcome a series of engineering obstacles. In microscopic dimensions, almost every aspect of machine operation needs to be rethought, and functional and motion problems are particularly troublesome. And the work to be done in the human body brings additional restrictions: you need to track where the objects are, and make sure they are non-toxic and harmless, and they must be designed to be harmlessly degradable or Leave the body.
"I think it should take a few years, and this field will be able to handle some basic issues," Nelson said. Now, he added, the focus of the problem becomes what the technicians can do with their hands.
Medicine is embracing miniaturization, and now some technologies also allow machines to pass through the body without external control. For example, a battery-powered pill-sized robot can take images as they pass through the esophagus, intestines, and colon.
In 2012, the US Food and Drug Administration opened a green light for Proteus Digital Health, based in Redwood City, Calif., to enable its smaller swallowable technology to be marketed. Their products can speak a square. The millimeter silicon circuit is embedded in a pill.
"This is the world's smallest digestible computer," said Markus Christen, a senior vice president at Proteus. Then he pointed out that its computing power is very limited. This Proteus chip does not carry an antenna or carry a battery. Instead, it contains two electrode materials that, when the pellet around the chip degrades, the circuit will contact the gastric phase in the stomach to achieve electrical conduction between the two electrodes. It takes only 5 to 10 minutes for the chip to get enough energy (between 1 milliwatt and 10 milliwatts) to modulate the current and then send a unique identification code to the device attached to the external skin.
Proteus chips are only upstream of the micro-robot industry. The chip is more than enough, Christen said, enough to help patients track drug consumption, and to help pharmaceutical companies monitor the drug in clinical trials when testing new drugs.
Nucleic Acid (DNA/RNA) Extraction Kit
1. Introduction
The total viral nucleic acid extraction kit is suitable for extracting total viral nucleic acid from serum, plasma, tissue homogenate and other samples. The kit is based on silica column purification technology, which eliminates the need for toxic phenol-chloroform extraction and time-consuming alcohol precipitation. This product has successfully extracted nucleic acids from hepatitis B A/C, hepatitis C, and norovirus standard. The obtained DNA/RNA can be directly used in a series of downstream experiments such as PCR, RT-PCR, and LAMP.
Notice:
1. The carrier RNA solid must be dissolved in Nuclease Free Water to 1µg/µl before use, and vortex to dissolve. Store in aliquots at -70°C. If you need to store it at -20℃ for a long time, please repackage it according to the number of times of use.
2. Dissolve Proteinase K (20mg/ml): Add Proteinase Dissolve Buffer to dissolve Proteinase K to a final concentration of 20mg/ml. Proteinase K dry powder can be stored at 2-8°C for one year, but dissolved Proteinase K must be stored in aliquots at -20°C. Repeated freezing and thawing of Proteinase K can affect its activity.
3. Buffer VHB must be diluted with 14 ml absolute ethanol before use and stored at room temperature.
4. Buffer RW2 must be diluted with 80 ml of absolute ethanol before use and stored at room temperature.
3. Shelf life
Except for Proteinase K and Carrier RNA, other components of this product can be stored at room temperature (15-25°C) for 12 months, and should be stored at 2-8°C for long-term storage. Proteinase K and Carrier RNA dry powder are transported at room temperature. Please store at -20°C after receiving the test product, and store at -20°C after dissolving.
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